An incredible range of scientific projects
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Center for Applied Scientific Computing

Application Areas

CASC is looking for creative team members at all stages of their careers. We invite you to browse the information below and apply to our open positions. Please contact us with any questions.

LLNL has a long history of technical innovation—from the wide range of incredible scientific projects and exceptional computational capabilities to our state-of-the-art experimental facilities and an HPC center housing some of the world’s largest supercomputers.

Mission-driven applications represent a unique opportunity to fundamentally advance the underlying disciplines. ML and data science in general are crucial to dealing with the massive simulations and complex experimental data generated at the Lab.

CASC researchers contribute to projects such as cancer biology, drug discovery, nuclear fusion, material design, clean energy, traumatic brain injuries, and transportation security. We are often called upon to help with national priorities such as the COVID pandemic.

We’re looking for creative, dedicated individuals who can advance, adapt, and apply the latest ML technologies as part of diverse, multidisciplinary teams comprising ML experts, software developers, domain scientists, and HPC specialists.

charts showing comparisons of the marginals of posteriors

Calibration with NN Surrogates

Calibration of an agent-based epidemiological model (EpiCast) uses simulation ensembles for different U.S. metro areas. Peer review pending.

Graphs showing business opening policy optimization results

ML Optimization in Epidemiology

A pandemic-relevant paper investigates optimal policy recommendations in healthcare. Peer review pending.

simulation of arterial blood flow

Coarctation of the Aorta

CASC researcher Erik Draeger and team combine ML, 3D printing, and simulations to model aortic blood flow.

latent space error graphed

Topological Data Analysis

We evaluate data-driven models in scientific applications such as HED physics and computational biology.

Data Skeptic podcast logo

Data Skeptic Podcast

CASC researcher Jay Thiagarajan discusses reliable, interpretable predictive models for healthcare applications.

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Parallelizing Training of DNNs

A novel tournament method trains traditional and generative adversarial networks for inertial confinement fusion.

parcellation of brain to 84 different regions

Modeling Human Brain Connectomes

The Human Connectome Project meets a structured network architecture to predict meta-information.

composite image of NIF target bay and supercomputer

DL-Based Surrogate Models

Surrogate models supported by neural networks could lead to new insights in complicated physics problems.